PDB entry 3cx5

View 3cx5 on RCSB PDB site
Description: Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.
Class: oxidoreductase
Keywords: COMPLEX III, CYTOCHROME C, ELECTRON TRANSFER COMPLEX, CYTOCHROME BC1 COMPLEX, MITOCHONDRIALTRANSMEMBRANE COMPLEX, RESPIRATORY CHAIN, TRANSIENT PROTEIN-PROTEIN INTERACTION, Electron transport, Inner membrane, Mitochondrion, Transit peptide, Transport, Phosphoprotein, Heme, Iron, Metal-binding, 2Fe-2S, Iron-sulfur, Oxidoreductase, Methylation
Deposited on 2008-04-23, released 2008-05-13
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.245
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome b-c1 complex subunit 1, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07256 (0-430)
      • conflict (126)
    Domains in SCOPe 2.01: d3cx5a1, d3cx5a2
  • Chain 'B':
    Compound: Cytochrome b-c1 complex subunit 2, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5b1, d3cx5b2
  • Chain 'C':
    Compound: cytochrome b
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5c1, d3cx5c2
  • Chain 'D':
    Compound: Cytochrome c1, heme protein, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5d1, d3cx5d2
  • Chain 'E':
    Compound: Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5e1, d3cx5e2
  • Chain 'F':
    Compound: Cytochrome b-c1 complex subunit 6
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5f1
  • Chain 'G':
    Compound: Cytochrome b-c1 complex subunit 7
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5g_
  • Chain 'H':
    Compound: Cytochrome b-c1 complex subunit 8
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5h_
  • Chain 'I':
    Compound: Cytochrome b-c1 complex subunit 9
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5i_
  • Chain 'J':
    Compound: heavy chain (vh) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-126)
    Domains in SCOPe 2.01: d3cx5j_
  • Chain 'K':
    Compound: light chain (vl) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-106)
    Domains in SCOPe 2.01: d3cx5k_
  • Chain 'L':
    Compound: Cytochrome b-c1 complex subunit 1, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07256 (0-430)
      • conflict (126)
    Domains in SCOPe 2.01: d3cx5l1, d3cx5l2
  • Chain 'M':
    Compound: Cytochrome b-c1 complex subunit 2, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5m1, d3cx5m2
  • Chain 'N':
    Compound: cytochrome b
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5n1, d3cx5n2
  • Chain 'O':
    Compound: Cytochrome c1, heme protein, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5o1, d3cx5o2
  • Chain 'P':
    Compound: Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5p1, d3cx5p2
  • Chain 'Q':
    Compound: Cytochrome b-c1 complex subunit 6
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5q1
  • Chain 'R':
    Compound: Cytochrome b-c1 complex subunit 7
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5r_
  • Chain 'S':
    Compound: Cytochrome b-c1 complex subunit 8
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5s_
  • Chain 'T':
    Compound: Cytochrome b-c1 complex subunit 9
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5t_
  • Chain 'U':
    Compound: heavy chain (vh) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-126)
    Domains in SCOPe 2.01: d3cx5u_
  • Chain 'V':
    Compound: light chain (vl) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-106)
    Domains in SCOPe 2.01: d3cx5v_
  • Chain 'W':
    Compound: Cytochrome c iso-1
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3cx5w_
  • Heterogens: SUC, 6PH, UMQ, HEM, SMA, 8PE, 9PE, CN5, 7PH, CN3, FES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5A (A:)
    aevtqlsngivvatehnpsahtasvgvvfgsgaanenpynngvsnlwkniflskensava
    akeglalssnisrdfqsyivsslpgstdksldflnqsfiqqkanllsssnfeatkksvlk
    qvqdfedndhpnrvlehlhstafqntplslptrgtleslenlvvadlesfannhflnsna
    vvvgtgnikhedlvnsiesknlslqtgtkpvlkkkaaflgsevrlrddtlpkawislave
    gepvnspnyfvaklaaqifgsynafepasrlqgiklldniqeyqlcdnfnhfslsykdsg
    lwgfstatrnvtmiddlihftlkqwnrltisvtdteveraksllklqlgqlyesgnpvnd
    anllgaevlikgsklslgeafkkidaitvkdvkawagkrlwdqdiaiagtgqieglldym
    rirsdmsmmrw
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5B (B:)
    ltvsardaptkistlavkvhggsryatkdgvahllnrfnfqntntrsalklvresellgg
    tfkstldreyitlkatflkddlpyyvnaladvlyktafkpheltesvlpaarydyavaeq
    cpvksaedqlyaitfrkglgnpllydgvervslqdikdfadkvytkenlevsgenvvead
    lkrfvdesllstlpagkslvsksepkfflgeenrvrfigdsvaaigipvnkaslaqyevl
    anyltsalselsglissakldkftdgglftlfvrdqdsavvssnikkivadlkkgkdlsp
    ainytklknavqnesvsspielnfdavkdfklgkfnyvavgdvsnlpyldel
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5C (C:)
    mafrksnvylslvnsyiidspqpssinywwnmgsllglclviqivtgifmamhyssniel
    afssvehimrdvhngyilrylhangasfffmvmfmhmakglyygsyrsprvtlwnvgvii
    filtiataflgyccvygqmshwgatvitnlfsaipfvgndivswlwggfsvsnptiqrff
    alhylvpfiiaamvimhlmalhihgssnplgitgnldripmhsyfifkdlvtvflfmlil
    alfvfyspntlghpdnyipgnplvtpasivpewyllpfyailrsipdkllgvitmfaail
    vllvlpftdrsvvrgntfkvlskffffifvfnfvllgqigachvevpyvlmgqiatfiyf
    ayfliivpvistienvlfyigrvnk
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5D (D:)
    mtaaehglhapayawshngpfetfdhasirrgyqvyrevcaachsldrvawrtlvgvsht
    neevrnmaeefeyddepdeqgnpkkrpgklsdyipgpypneqaaraanqgalppdlsliv
    karhggcdyifslltgypdeppagvalppgsnynpyfpggsiamarvlfddmveyedgtp
    attsqmakdvttflnwcaepehderkrlglktviilsslyllsiwvkkfkwagiktrkfv
    fnppkprk
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5E (E:)
    kstyrtpnfddvlkenndadkgrsyayfmvgamgllssagakstvetfissmtatadvla
    makvevnlaaiplgknvvvkwqgkpvfirhrtpheiqeansvdmsalkdpqtdadrvkdp
    qwlimlgicthlgcvpigeagdfggwfcpchgshydisgrirkgpaplnleipayefdgd
    kvivg
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >3cx5F (F:)
    gmlelvgeyweqlkitvvpvvaaaedddneqheekaaegeekeeengdedededededdd
    ddddedeeeeeevtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehke
    dcveeffhlqhyldtataprlfdklk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cx5F (F:)
    vtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehkedcveeffhlqhy
    ldtataprlfdklk
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5G (G:)
    pqsftsiarigdyilkspvlsklcvpvanqfinlagykklglkfddliaeenpimqtalr
    rlpedesyarayriirahqtelthhllprnewikaqedvpyllpyileaeaaakekdeld
    nievsk
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5H (H:)
    gppsgktymgwwghmggpkqkgitsyavspyaqkplqgifhnavfnsfrrfksqflyvli
    pagiywywwkngneyneflyskagreelervnv
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >3cx5I (I:)
    sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaagdg
    dddde
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cx5I (I:)
    sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaa
    

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5J (J:)
    evklqesgaglvqpsqslsltcsvtgysitsgyywnwirlfpgnklewvgyisnvgdnny
    npslkdrlsitrdtsknqfflklnsvttedtatyycarseyysvtgyamdywgqgttvtv
    ssawrhp
    

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5K (K:)
    dieltqtpvslaaslgdrvtiscrasqdinnflnwyqqkpdgtiklliyytsrlhagvps
    rfsgsgsgtdysltisnlepediatyfcqhhikfpwtfgagtkleik
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5L (L:)
    aevtqlsngivvatehnpsahtasvgvvfgsgaanenpynngvsnlwkniflskensava
    akeglalssnisrdfqsyivsslpgstdksldflnqsfiqqkanllsssnfeatkksvlk
    qvqdfedndhpnrvlehlhstafqntplslptrgtleslenlvvadlesfannhflnsna
    vvvgtgnikhedlvnsiesknlslqtgtkpvlkkkaaflgsevrlrddtlpkawislave
    gepvnspnyfvaklaaqifgsynafepasrlqgiklldniqeyqlcdnfnhfslsykdsg
    lwgfstatrnvtmiddlihftlkqwnrltisvtdteveraksllklqlgqlyesgnpvnd
    anllgaevlikgsklslgeafkkidaitvkdvkawagkrlwdqdiaiagtgqieglldym
    rirsdmsmmrw
    

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5M (M:)
    ltvsardaptkistlavkvhggsryatkdgvahllnrfnfqntntrsalklvresellgg
    tfkstldreyitlkatflkddlpyyvnaladvlyktafkpheltesvlpaarydyavaeq
    cpvksaedqlyaitfrkglgnpllydgvervslqdikdfadkvytkenlevsgenvvead
    lkrfvdesllstlpagkslvsksepkfflgeenrvrfigdsvaaigipvnkaslaqyevl
    anyltsalselsglissakldkftdgglftlfvrdqdsavvssnikkivadlkkgkdlsp
    ainytklknavqnesvsspielnfdavkdfklgkfnyvavgdvsnlpyldel
    

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5N (N:)
    mafrksnvylslvnsyiidspqpssinywwnmgsllglclviqivtgifmamhyssniel
    afssvehimrdvhngyilrylhangasfffmvmfmhmakglyygsyrsprvtlwnvgvii
    filtiataflgyccvygqmshwgatvitnlfsaipfvgndivswlwggfsvsnptiqrff
    alhylvpfiiaamvimhlmalhihgssnplgitgnldripmhsyfifkdlvtvflfmlil
    alfvfyspntlghpdnyipgnplvtpasivpewyllpfyailrsipdkllgvitmfaail
    vllvlpftdrsvvrgntfkvlskffffifvfnfvllgqigachvevpyvlmgqiatfiyf
    ayfliivpvistienvlfyigrvnk
    

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5O (O:)
    mtaaehglhapayawshngpfetfdhasirrgyqvyrevcaachsldrvawrtlvgvsht
    neevrnmaeefeyddepdeqgnpkkrpgklsdyipgpypneqaaraanqgalppdlsliv
    karhggcdyifslltgypdeppagvalppgsnynpyfpggsiamarvlfddmveyedgtp
    attsqmakdvttflnwcaepehderkrlglktviilsslyllsiwvkkfkwagiktrkfv
    fnppkprk
    

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5P (P:)
    kstyrtpnfddvlkenndadkgrsyayfmvgamgllssagakstvetfissmtatadvla
    makvevnlaaiplgknvvvkwqgkpvfirhrtpheiqeansvdmsalkdpqtdadrvkdp
    qwlimlgicthlgcvpigeagdfggwfcpchgshydisgrirkgpaplnleipayefdgd
    kvivg
    

  • Chain 'Q':
    Sequence, based on SEQRES records: (download)
    >3cx5Q (Q:)
    gmlelvgeyweqlkitvvpvvaaaedddneqheekaaegeekeeengdedededededdd
    ddddedeeeeeevtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehke
    dcveeffhlqhyldtataprlfdklk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cx5Q (Q:)
    vtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehkedcveeffhlqhy
    ldtataprlfdklk
    

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5R (R:)
    pqsftsiarigdyilkspvlsklcvpvanqfinlagykklglkfddliaeenpimqtalr
    rlpedesyarayriirahqtelthhllprnewikaqedvpyllpyileaeaaakekdeld
    nievsk
    

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5S (S:)
    gppsgktymgwwghmggpkqkgitsyavspyaqkplqgifhnavfnsfrrfksqflyvli
    pagiywywwkngneyneflyskagreelervnv
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >3cx5T (T:)
    sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaagdg
    dddde
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cx5T (T:)
    sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaa
    

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5U (U:)
    evklqesgaglvqpsqslsltcsvtgysitsgyywnwirlfpgnklewvgyisnvgdnny
    npslkdrlsitrdtsknqfflklnsvttedtatyycarseyysvtgyamdywgqgttvtv
    ssawrhp
    

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5V (V:)
    dieltqtpvslaaslgdrvtiscrasqdinnflnwyqqkpdgtiklliyytsrlhagvps
    rfsgsgsgtdysltisnlepediatyfcqhhikfpwtfgagtkleik
    

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3cx5W (W:)
    tefkagsakkgatlfktrclqchtvekggphkvgpnlhgifgrhsgqaegysytdanikk
    nvlwdennmseyltnpkkyipgtkmafgglkkekdrndlitylkkace