PDB entry 3cx5

View 3cx5 on RCSB PDB site
Description: Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.
Class: oxidoreductase
Keywords: COMPLEX III, CYTOCHROME C, ELECTRON TRANSFER COMPLEX, CYTOCHROME BC1 COMPLEX, MITOCHONDRIALTRANSMEMBRANE COMPLEX, RESPIRATORY CHAIN, TRANSIENT PROTEIN-PROTEIN INTERACTION, Electron transport, Inner membrane, Mitochondrion, Transit peptide, Transport, Phosphoprotein, Heme, Iron, Metal-binding, 2Fe-2S, Iron-sulfur, Oxidoreductase, Methylation
Deposited on 2008-04-23, released 2008-05-13
The last revision prior to the SCOP 1.75 freeze date was dated 2008-07-01, with a file datestamp of 2008-06-27.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.245
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome b-c1 complex subunit 1, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07256 (0-430)
      • conflict (126)
    Domains in SCOP 1.75: d3cx5a1, d3cx5a2
  • Chain 'B':
    Compound: Cytochrome b-c1 complex subunit 2, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5b1, d3cx5b2
  • Chain 'C':
    Compound: cytochrome b
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5c1, d3cx5c2
  • Chain 'D':
    Compound: Cytochrome c1, heme protein, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5d1, d3cx5d2
  • Chain 'E':
    Compound: Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5e1, d3cx5e2
  • Chain 'F':
    Compound: Cytochrome b-c1 complex subunit 6
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5f1
  • Chain 'G':
    Compound: Cytochrome b-c1 complex subunit 7
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5g1
  • Chain 'H':
    Compound: Cytochrome b-c1 complex subunit 8
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5h1
  • Chain 'I':
    Compound: Cytochrome b-c1 complex subunit 9
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5i1
  • Chain 'J':
    Compound: heavy chain (vh) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-126)
    Domains in SCOP 1.75: d3cx5j1
  • Chain 'K':
    Compound: light chain (vl) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-106)
    Domains in SCOP 1.75: d3cx5k1
  • Chain 'L':
    Compound: Cytochrome b-c1 complex subunit 1, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07256 (0-430)
      • conflict (126)
    Domains in SCOP 1.75: d3cx5l1, d3cx5l2
  • Chain 'M':
    Compound: Cytochrome b-c1 complex subunit 2, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5m1, d3cx5m2
  • Chain 'N':
    Compound: cytochrome b
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5n1, d3cx5n2
  • Chain 'O':
    Compound: Cytochrome c1, heme protein, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5o1, d3cx5o2
  • Chain 'P':
    Compound: Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5p1, d3cx5p2
  • Chain 'Q':
    Compound: Cytochrome b-c1 complex subunit 6
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5q1
  • Chain 'R':
    Compound: Cytochrome b-c1 complex subunit 7
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5r1
  • Chain 'S':
    Compound: Cytochrome b-c1 complex subunit 8
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5s1
  • Chain 'T':
    Compound: Cytochrome b-c1 complex subunit 9
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cx5t1
  • Chain 'U':
    Compound: heavy chain (vh) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-126)
    Domains in SCOP 1.75: d3cx5u1
  • Chain 'V':
    Compound: light chain (vl) of fv-fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3CX5 (0-106)
    Domains in SCOP 1.75: d3cx5v1
  • Chain 'W':
    Compound: Cytochrome c iso-1
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SUC, 6PH, UMQ, HEM, SMA, 8PE, 9PE, CN5, 7PH, CN3, FES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5A (A:)
aevtqlsngivvatehnpsahtasvgvvfgsgaanenpynngvsnlwkniflskensava
akeglalssnisrdfqsyivsslpgstdksldflnqsfiqqkanllsssnfeatkksvlk
qvqdfedndhpnrvlehlhstafqntplslptrgtleslenlvvadlesfannhflnsna
vvvgtgnikhedlvnsiesknlslqtgtkpvlkkkaaflgsevrlrddtlpkawislave
gepvnspnyfvaklaaqifgsynafepasrlqgiklldniqeyqlcdnfnhfslsykdsg
lwgfstatrnvtmiddlihftlkqwnrltisvtdteveraksllklqlgqlyesgnpvnd
anllgaevlikgsklslgeafkkidaitvkdvkawagkrlwdqdiaiagtgqieglldym
rirsdmsmmrw

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5B (B:)
ltvsardaptkistlavkvhggsryatkdgvahllnrfnfqntntrsalklvresellgg
tfkstldreyitlkatflkddlpyyvnaladvlyktafkpheltesvlpaarydyavaeq
cpvksaedqlyaitfrkglgnpllydgvervslqdikdfadkvytkenlevsgenvvead
lkrfvdesllstlpagkslvsksepkfflgeenrvrfigdsvaaigipvnkaslaqyevl
anyltsalselsglissakldkftdgglftlfvrdqdsavvssnikkivadlkkgkdlsp
ainytklknavqnesvsspielnfdavkdfklgkfnyvavgdvsnlpyldel

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5C (C:)
mafrksnvylslvnsyiidspqpssinywwnmgsllglclviqivtgifmamhyssniel
afssvehimrdvhngyilrylhangasfffmvmfmhmakglyygsyrsprvtlwnvgvii
filtiataflgyccvygqmshwgatvitnlfsaipfvgndivswlwggfsvsnptiqrff
alhylvpfiiaamvimhlmalhihgssnplgitgnldripmhsyfifkdlvtvflfmlil
alfvfyspntlghpdnyipgnplvtpasivpewyllpfyailrsipdkllgvitmfaail
vllvlpftdrsvvrgntfkvlskffffifvfnfvllgqigachvevpyvlmgqiatfiyf
ayfliivpvistienvlfyigrvnk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5D (D:)
mtaaehglhapayawshngpfetfdhasirrgyqvyrevcaachsldrvawrtlvgvsht
neevrnmaeefeyddepdeqgnpkkrpgklsdyipgpypneqaaraanqgalppdlsliv
karhggcdyifslltgypdeppagvalppgsnynpyfpggsiamarvlfddmveyedgtp
attsqmakdvttflnwcaepehderkrlglktviilsslyllsiwvkkfkwagiktrkfv
fnppkprk

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5E (E:)
kstyrtpnfddvlkenndadkgrsyayfmvgamgllssagakstvetfissmtatadvla
makvevnlaaiplgknvvvkwqgkpvfirhrtpheiqeansvdmsalkdpqtdadrvkdp
qwlimlgicthlgcvpigeagdfggwfcpchgshydisgrirkgpaplnleipayefdgd
kvivg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3cx5F (F:)
gmlelvgeyweqlkitvvpvvaaaedddneqheekaaegeekeeengdedededededdd
ddddedeeeeeevtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehke
dcveeffhlqhyldtataprlfdklk

    Sequence, based on observed residues (ATOM records): (download) 
    >3cx5F (F:)
vtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehkedcveeffhlqhy
ldtataprlfdklk

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5G (G:)
pqsftsiarigdyilkspvlsklcvpvanqfinlagykklglkfddliaeenpimqtalr
rlpedesyarayriirahqtelthhllprnewikaqedvpyllpyileaeaaakekdeld
nievsk

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5H (H:)
gppsgktymgwwghmggpkqkgitsyavspyaqkplqgifhnavfnsfrrfksqflyvli
pagiywywwkngneyneflyskagreelervnv

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >3cx5I (I:)
sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaagdg
dddde

    Sequence, based on observed residues (ATOM records): (download) 
    >3cx5I (I:)
sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaa

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5J (J:)
evklqesgaglvqpsqslsltcsvtgysitsgyywnwirlfpgnklewvgyisnvgdnny
npslkdrlsitrdtsknqfflklnsvttedtatyycarseyysvtgyamdywgqgttvtv
ssawrhp

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5K (K:)
dieltqtpvslaaslgdrvtiscrasqdinnflnwyqqkpdgtiklliyytsrlhagvps
rfsgsgsgtdysltisnlepediatyfcqhhikfpwtfgagtkleik

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5L (L:)
aevtqlsngivvatehnpsahtasvgvvfgsgaanenpynngvsnlwkniflskensava
akeglalssnisrdfqsyivsslpgstdksldflnqsfiqqkanllsssnfeatkksvlk
qvqdfedndhpnrvlehlhstafqntplslptrgtleslenlvvadlesfannhflnsna
vvvgtgnikhedlvnsiesknlslqtgtkpvlkkkaaflgsevrlrddtlpkawislave
gepvnspnyfvaklaaqifgsynafepasrlqgiklldniqeyqlcdnfnhfslsykdsg
lwgfstatrnvtmiddlihftlkqwnrltisvtdteveraksllklqlgqlyesgnpvnd
anllgaevlikgsklslgeafkkidaitvkdvkawagkrlwdqdiaiagtgqieglldym
rirsdmsmmrw

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5M (M:)
ltvsardaptkistlavkvhggsryatkdgvahllnrfnfqntntrsalklvresellgg
tfkstldreyitlkatflkddlpyyvnaladvlyktafkpheltesvlpaarydyavaeq
cpvksaedqlyaitfrkglgnpllydgvervslqdikdfadkvytkenlevsgenvvead
lkrfvdesllstlpagkslvsksepkfflgeenrvrfigdsvaaigipvnkaslaqyevl
anyltsalselsglissakldkftdgglftlfvrdqdsavvssnikkivadlkkgkdlsp
ainytklknavqnesvsspielnfdavkdfklgkfnyvavgdvsnlpyldel

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5N (N:)
mafrksnvylslvnsyiidspqpssinywwnmgsllglclviqivtgifmamhyssniel
afssvehimrdvhngyilrylhangasfffmvmfmhmakglyygsyrsprvtlwnvgvii
filtiataflgyccvygqmshwgatvitnlfsaipfvgndivswlwggfsvsnptiqrff
alhylvpfiiaamvimhlmalhihgssnplgitgnldripmhsyfifkdlvtvflfmlil
alfvfyspntlghpdnyipgnplvtpasivpewyllpfyailrsipdkllgvitmfaail
vllvlpftdrsvvrgntfkvlskffffifvfnfvllgqigachvevpyvlmgqiatfiyf
ayfliivpvistienvlfyigrvnk

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5O (O:)
mtaaehglhapayawshngpfetfdhasirrgyqvyrevcaachsldrvawrtlvgvsht
neevrnmaeefeyddepdeqgnpkkrpgklsdyipgpypneqaaraanqgalppdlsliv
karhggcdyifslltgypdeppagvalppgsnynpyfpggsiamarvlfddmveyedgtp
attsqmakdvttflnwcaepehderkrlglktviilsslyllsiwvkkfkwagiktrkfv
fnppkprk

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5P (P:)
kstyrtpnfddvlkenndadkgrsyayfmvgamgllssagakstvetfissmtatadvla
makvevnlaaiplgknvvvkwqgkpvfirhrtpheiqeansvdmsalkdpqtdadrvkdp
qwlimlgicthlgcvpigeagdfggwfcpchgshydisgrirkgpaplnleipayefdgd
kvivg

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >3cx5Q (Q:)
gmlelvgeyweqlkitvvpvvaaaedddneqheekaaegeekeeengdedededededdd
ddddedeeeeeevtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehke
dcveeffhlqhyldtataprlfdklk

    Sequence, based on observed residues (ATOM records): (download) 
    >3cx5Q (Q:)
vtdqledlrehfknteegkalvhhyeecaervkiqqqqpgyadlehkedcveeffhlqhy
ldtataprlfdklk

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5R (R:)
pqsftsiarigdyilkspvlsklcvpvanqfinlagykklglkfddliaeenpimqtalr
rlpedesyarayriirahqtelthhllprnewikaqedvpyllpyileaeaaakekdeld
nievsk

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5S (S:)
gppsgktymgwwghmggpkqkgitsyavspyaqkplqgifhnavfnsfrrfksqflyvli
pagiywywwkngneyneflyskagreelervnv

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >3cx5T (T:)
sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaagdg
dddde

    Sequence, based on observed residues (ATOM records): (download) 
    >3cx5T (T:)
sfsslyktffkrnavfvgtifagafvfqtvfdtaitswyenhnkgklwkdvkariaa

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5U (U:)
evklqesgaglvqpsqslsltcsvtgysitsgyywnwirlfpgnklewvgyisnvgdnny
npslkdrlsitrdtsknqfflklnsvttedtatyycarseyysvtgyamdywgqgttvtv
ssawrhp

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cx5V (V:)
dieltqtpvslaaslgdrvtiscrasqdinnflnwyqqkpdgtiklliyytsrlhagvps
rfsgsgsgtdysltisnlepediatyfcqhhikfpwtfgagtkleik

  • Chain 'W':
    No sequence available.