PDB entry 3cu1
View 3cu1 on RCSB PDB site
Description: Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex
Class: Transferase/Hormone
Keywords: Fibroblast growth factor 1, Fibroblast growth factor receptor 2, D2 domain, sucrose octa sulfate, Alternative splicing, ATP-binding, Disease mutation, Ectodermal dysplasia, Glycoprotein, Heparin-binding, Immunoglobulin domain, Kinase, Lacrimo-auriculo-dento-digital syndrome, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Acetylation, Angiogenesis, Developmental protein, Differentiation, Mitogen, Transferase-Hormone COMPLEX
Deposited on
2008-04-15, released
2009-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-07-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.23
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Fibroblast growth factor receptor 2
Species: HOMO SAPIENS
Gene: FGFR2, BEK, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3cu1a_ - Chain 'B':
Compound: heparin-binding growth factor 1
Species: HOMO SAPIENS
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3cu1b_ - Chain 'C':
Compound: Fibroblast growth factor receptor 2
Species: HOMO SAPIENS
Gene: FGFR2, BEK, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3cu1c_ - Chain 'D':
Compound: heparin-binding growth factor 1
Species: HOMO SAPIENS
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3cu1d_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3cu1A (A:)
nkrapywtntekmekrlhavpaantvkfrcpaggnpmptmrwlkngkefkqehriggykv
rnqhwslimesvvpsdkgnytcvveneygsinhtyhldvv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3cu1B (B:)
nykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyikstetgqyla
mdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngsckrgprthyg
qkailflplpv
Sequence, based on observed residues (ATOM records): (download)
>3cu1B (B:)
kpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyikstetgqylamdt
dgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngsckrgprthygqka
ilflplpv
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>3cu1C (C:)
nkrapywtntekmekrlhavpaantvkfrcpaggnpmptmrwlkngkefkqehriggykv
rnqhwslimesvvpsdkgnytcvveneygsinhtyhldvv
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>3cu1D (D:)
nykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyikstetgqyla
mdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngsckrgprthyg
qkailflplpv