PDB entry 3cjf

View 3cjf on RCSB PDB site
Description: Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
Class: transferase
Keywords: Vascular endothelial growth factor receptor 2. vegfr-2, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, Angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphoprotein, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-03-12, released 2008-10-07
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.205
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: HOMO SAPIENS
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-133)
      • see remark 999 (29)
    • Uniprot P35968 (Start-308)
    Domains in SCOPe 2.02: d3cjfa_
  • Heterogens: SO4, SAV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cjfA (A:)
mdpdelpldehcerlpydaskwefprdrlnlgkplgrgafgqvieadafgidktatcrtv
avkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnls
tylrskrnefvpykdlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillsek
nvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweif
slgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselveh
lgnllqana

    Sequence, based on observed residues (ATOM records): (download) 
    >3cjfA (A:)
cerlpydaskwefprdrlnlgkplgrgafgqvieadafgidktatcrtvavkmlkegath
sehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefv
pykkdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdlardiyk
plkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmra
pdyttpemyqtmldcwhgepsqrptfselvehlgnllqana