PDB entry 3cii

View 3cii on RCSB PDB site
Description: Structure of NKG2A/CD94 bound to HLA-E
Class: immune system
Keywords: C-type lectin-like, Glycoprotein, Immune response, Membrane, MHC I, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, Lectin, Receptor, Signal-anchor, IMMUNE SYSTEM
Deposited on 2008-03-11, released 2008-05-13
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 4.41 Å
R-factor: 0.321
AEROSPACI score: -0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3ciia1, d3ciia2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.02: d3ciib1
  • Chain 'C':
    Compound: HLA class I histocompatibility antigen peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3ciid1, d3ciid2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.02: d3ciie1
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Natural killer cells antigen CD94
    Species: Homo sapiens [TaxId:9606]
    Gene: KLRD1, CD94
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3ciig1
  • Chain 'H':
    Compound: NKG2-A/NKG2-B type II integral membrane protein
    Species: Homo sapiens [TaxId:9606]
    Gene: KLRC1, NKG2A
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Natural killer cells antigen CD94
    Species: Homo sapiens [TaxId:9606]
    Gene: KLRD1, CD94
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3ciii1
  • Chain 'J':
    Compound: NKG2-A/NKG2-B type II integral membrane protein
    Species: Homo sapiens [TaxId:9606]
    Gene: KLRC1, NKG2A
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiA (A:)
    shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
    retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
    dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
    leppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgtf
    qkwaavvvpsgeeqrytchvqheglpepvtlrw
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiD (D:)
    shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
    retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
    dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
    leppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgtf
    qkwaavvvpsgeeqrytchvqheglpepvtlrw
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiE (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiG (G:)
    cscqekwvgyrcncyfisseqktwnesrhlcasqkssllqlqntdeldfmsssqqfywig
    lsyseehtawlwengsalsqylfpsfetfntknciaynpngnaldescedknryickqql
    i
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3ciiI (I:)
    cscqekwvgyrcncyfisseqktwnesrhlcasqkssllqlqntdeldfmsssqqfywig
    lsyseehtawlwengsalsqylfpsfetfntknciaynpngnaldescedknryickqql
    i
    

  • Chain 'J':
    No sequence available.