PDB entry 3cgf

View 3cgf on RCSB PDB site
Description: IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
Class: transferase
Keywords: kinase two-lobed structure, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2008-03-05, released 2008-06-03
The last revision prior to the SCOP 1.75 freeze date was dated 2008-06-10, with a file datestamp of 2008-06-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.225
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: HOMO SAPIENS
    Gene: MAPK10, JNK3, JNK3A, PRKM10
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cgfa1
  • Heterogens: JNF

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cgfA (A:)
mgskskvdnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsr
pfqnqthakrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqvi
qmeldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagts
fmmtpyvvtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvie
qlgtpcpefmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardlls
kmlvidpakrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliyke
vmnse

    Sequence, based on observed residues (ATOM records): (download) 
    >3cgfA (A:)
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglasfmmtpyvvtryy
rapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkk
lqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakris
vddalqhpyinvwydpaeveapppqlderehtieewkeliykevmn