PDB entry 3ccn

View 3ccn on RCSB PDB site
Description: X-ray structure of c-Met with triazolopyridazine inhibitor.
Class: transferase
Keywords: c-Met Kinase Triazolopyridazine, ATP-binding, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-02-26, released 2008-04-29
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.238
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581
      • variant (225)
    Domains in SCOPe 2.02: d3ccna_
  • Heterogens: LKG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ccnA (A:)
    mqntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkih
    cavkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlr
    nfirnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfgla
    rdmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypd
    vntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig
    ehyvhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ccnA (A:)
    lsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlkihcavkslnrevsqfl
    tegiimkdfshpnvlsllgiclplvvlpymkhgdlrnfirnethnptvkdligfglqvak
    gmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhktgaklpvkwma
    leslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdp
    lyevmlkcwhpkaemrpsfselvsrisaifstfig