PDB entry 3cas

View 3cas on RCSB PDB site
Description: Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 4-androstenedione
Class: oxidoreductase
Keywords: 5b-reductase, 5beta-reductase, 5b-red, AKR1D1, AKR, aldo-keto reductase, NADP, androstenedione, NADPH, substrate inhibition, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, Oxidoreductase, Steroid metabolism
Deposited on 2008-02-20, released 2008-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3casa_
  • Chain 'B':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3casb_
  • Heterogens: NAP, BME, EDO, ASD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3casA (A:)
    mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
    ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
    vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
    nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
    dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
    alnknvrfvellmwrdhpeypfhdey
    

    Sequence, based on observed residues (ATOM records): (download)
    >3casA (A:)
    dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
    hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
    pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
    kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
    allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
    lnknvrfvellmwrdhpeypfhdey
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3casB (B:)
    mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
    ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
    vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
    nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
    dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
    alnknvrfvellmwrdhpeypfhdey
    

    Sequence, based on observed residues (ATOM records): (download)
    >3casB (B:)
    dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
    hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
    pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
    kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
    allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
    lnknvrfvellmwrdhpeypfhdey