PDB entry 3c2k

View 3c2k on RCSB PDB site
Description: DNA POLYMERASE BETA with a gapped DNA substrate and DUMPNPP with Manganese in the active site
Class: transferase/DNA
Keywords: Nucleotidyl Transferase, DNA Polymerase, Misincorporation, Manganese, DNA damage, DNA repair, DNA replication, DNA synthesis, DNA-binding, DNA-directed DNA polymerase, Lyase, Magnesium, Metal-binding, Nucleotidyltransferase, Nucleus, Polymorphism, Sodium, TRANSFERASE/DNA COMPLEX
Deposited on 2008-01-25, released 2008-05-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.21
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase beta
    Species: HOMO SAPIENS
    Gene: POLB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3c2ka1, d3c2ka2, d3c2ka3
  • Chain 'D':
    Compound: DNA (5'-d(p*dgp*dtp*dcp*dgp*dg)-3')
  • Chain 'P':
    Compound: DNA (5'-d(*dgp*dcp*dtp*dgp*dap*dtp*dgp*dcp*dgp*dc)-3')
  • Chain 'T':
    Compound: DNA (5'-d(*dcp*dcp*dgp*dap*dcp*dap*dgp*dcp*dgp*dcp*dap*dtp*dcp*dap*dgp*dc)-3')
  • Heterogens: MN, NA, CL, DUP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c2kA (A:)
mskrkapqetlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeak
klpgvgtkiaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegik
tledlrknedklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgs
frrgaessgdmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcq
lpskndekeyphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirp
lgvtgvageplpvdsekdifdyiqwkyrepkdrse

    Sequence, based on observed residues (ATOM records): (download) 
    >3c2kA (A:)
tlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeakklpgvgtki
aekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegiktledlrkne
dklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgsfrrgaessg
dmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcqlpskndeke
yphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirplgvtgvage
plpvdsekdifdyiqwkyrepkdrse

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.