PDB entry 3bgq

View 3bgq on RCSB PDB site
Description: Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2
Class: Transferase
Keywords: kinase inhibitor phosphorylation, Alternative initiation, ATP-binding, Cytoplasm, Manganese, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, Serine/threonine-protein kinase, Transferase
Deposited on 2007-11-27, released 2007-12-11
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.213
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3bgqa1
  • Heterogens: VX2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3bgqA (A:)
mgsshhhhhhssglvprgshmllskinslahlraapcndlhatklapgkekeplesqyqv
gpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgf
sgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhchn
cgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryhg
rsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrpt
feeiqnhpwmqdvllpqetaeihlhslspgpsk

    Sequence, based on observed residues (ATOM records): (download) 
    >3bgqA (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh