PDB entry 3b6f

View 3b6f on RCSB PDB site
Description: Nucleosome core particle treated with cisplatin
Class: structural protein/DNA
Keywords: nucleosome, chromatin, platinum adduct, cisplatin, anti-cancer, drug, Acetylation, Chromosomal protein, DNA-binding, Methylation, Nucleosome core, Nucleus, Phosphorylation, Ubl conjugation, STRUCTURAL PROTEIN/DNA COMPLEX
Deposited on 2007-10-29, released 2007-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.45 Å
R-factor: 0.331
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233 (Start-134)
      • conflict (101)
    Domains in SCOPe 2.08: d3b6fa1
  • Chain 'B':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3b6fb1
  • Chain 'C':
    Compound: histone h2a
    Species: Xenopus laevis [TaxId:8355]
    Gene: LOC494591
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3b6fc1
  • Chain 'D':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281 (Start-124)
      • conflict (31)
    Domains in SCOPe 2.08: d3b6fd1
  • Chain 'E':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233 (Start-134)
      • conflict (101)
    Domains in SCOPe 2.08: d3b6fe1
  • Chain 'F':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3b6ff1
  • Chain 'G':
    Compound: histone h2a
    Species: Xenopus laevis [TaxId:8355]
    Gene: LOC494591
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3b6fg1
  • Chain 'H':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281 (Start-124)
      • conflict (31)
    Domains in SCOPe 2.08: d3b6fh1
  • Chain 'I':
    Compound: 147-mer DNA
    Species: Homo sapiens [TaxId:9606]
  • Chain 'J':
    Compound: 147-mer DNA
    Species: Homo sapiens [TaxId:9606]
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3b6fA (A:)
artkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkstel
lirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvalfedtnlcaihakrvtim
pkdiqlarrirgera

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fA (A:)
ggvkkphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmal
qeaseaylvalfedtnlcaihakrvtimpkdiqlarrirgera

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3b6fB (B:)
sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fB (B:)
dniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrktvta
mdvvyalkrqgrtlygfgg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3b6fC (C:)
sgrgkqggktrakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt
essksksk

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fC (C:)
ktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaardnk
ktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3b6fD (D:)
pepaksapapkkgskkavtktqkkdgkkrrktrkesyaiyvykvlkqvhpdtgisskams
imnsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtk
ytsak

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fD (D:)
dgkkrrktrkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahyn
krstitsreiqtavrlllpgelakhavsegtkavtkytsak

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3b6fE (E:)
artkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkstel
lirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvalfedtnlcaihakrvtim
pkdiqlarrirgera

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fE (E:)
atggvkkphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavm
alqeaseaylvalfedtnlcaihakrvtimpkdiqlarrirgera

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3b6fF (F:)
sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fF (F:)
krhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtyteh
akrktvtamdvvyalkrqgrtlygfgg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3b6fG (G:)
sgrgkqggktrakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt
essksksk

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fG (G:)
kaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaard
nkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkte

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3b6fH (H:)
pepaksapapkkgskkavtktqkkdgkkrrktrkesyaiyvykvlkqvhpdtgisskams
imnsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtk
ytsak

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6fH (H:)
kkrrktrkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkr
stitsreiqtavrlllpgelakhavsegtkavtkytsak

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.