PDB entry 3apd

View 3apd on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with CH5108134
Class: Transferase/Transferase inhibitor
Keywords: phosphoinositide 3-kinase gamma, Kinase, Transferase, Transferase-Transferase inhibitor complex
Deposited on 2010-10-14, released 2011-04-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-04-13, with a file datestamp of 2011-04-08.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.253
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3apda1, d3apda2, d3apda3, d3apda4
  • Heterogens: MMY, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3apdA (A:)
gplhmgsseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpkly
amhpwvtskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkk
slmdipesqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpald
evrkeewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprn
tdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycg
kapalsskasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgs
fnadkltsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqle
aiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrev
wdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsa
larfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqv
qviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagal
aiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwe
tesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkeksp
teekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksfl
ginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlm
tgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikq
gekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >3apdA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmaseqdfvlrvc
grdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkecdrkfrvkirgidi
pvlptdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlq
iycvqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisilld
nempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeiv
aktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlv
qavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgc
gtamlhdftqqvqviemlqkvtldikslsadvssqvisqlkqklenlqnsqlpesfrvpy
dpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqi
lrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ilgnnkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmm
lmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlg