PDB entry 3amb

View 3amb on RCSB PDB site
Description: Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: PKA, protein kinase A, surrogate, VX-680, MK-0457, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2010-08-18, released 2011-08-03
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-12-07, with a file datestamp of 2011-12-02.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.214
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKACA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17612 (Start-350)
      • engineered mutation (47)
      • engineered mutation (95)
      • engineered mutation (120)
      • engineered mutation (123)
      • engineered mutation (181)
      • engineered mutation (183)
    Domains in SCOPe 2.02: d3amba_
  • Chain 'B':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: VX6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ambA (A:)
mgnaaaakkgseqesvkeflakakedflkkwespaqntahldqferirtlgtgsfgrvml
vkhketgnhyamkildkqkvvklkqiehtlnekriqqavnfpflvklefsfkdnsnlymv
leyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgy
ikvadfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >3ambA (A:)
aaaakkgseqesvkeflakakedflkkwespaqntahldqferirtlgtgsfgrvmlvkh
ketgnhyamkildkqkvvklkqiehtlnekriqqavnfpflvklefsfkdnsnlymvley
apggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyikv
adfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadq
piqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdw
iaiyqrkveapfipkfksnfddyeeeeirvsinekcgkefsef

  • Chain 'B':
    No sequence available.