PDB entry 3ad6

View 3ad6 on RCSB PDB site
Description: Crystal structure of Pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)
Class: transferase
Keywords: tyrosine-protein kinase, ATP-binding, phosphorylation, signal transduction, kinase, sh2 domain, sh3 domain, transferase
Deposited on 2010-01-14, released 2011-01-19
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-01-19, with a file datestamp of 2011-01-14.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.192
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase LCK
    Species: Homo sapiens [TaxId:9606]
    Gene: LCK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ad6a_
  • Heterogens: SO4, DMS, KSC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ad6A (A:)
qtqkpqkpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspda
flaeanlmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldm
aaqiaegmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpi
kwtapeainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdn
cpeelyqlmrlcwkerpedrptfdylrsvledfftategqyqpqp

    Sequence, based on observed residues (ATOM records): (download) 
    >3ad6A (A:)
qkpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaea
nlmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqia
egmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtap
eainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeel
yqlmrlcwkerpedrptfdylrsvledfftate