PDB entry 3acj
View 3acj on RCSB PDB site
Description: Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human LCK, (Auto-phosphorylated on TYR394)
Class: transferase
Keywords: tyrosine-protein kinase, ATP-binding, phosphorylation, signal transduction, alternative splicing, kinase, sh2 domain, sh3 domain, transferase
Deposited on
2010-01-05, released
2010-06-30
The last revision prior to the SCOPe 2.02 freeze date was dated
2010-06-30, with a file datestamp of
2010-06-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.175
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase LCK
Species: Homo sapiens [TaxId:9606]
Gene: LCK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3acja_ - Heterogens: SO4, DMS, KSS, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3acjA (A:)
qtqkpqkpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspda
flaeanlmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldm
aaqiaegmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpi
kwtapeainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdn
cpeelyqlmrlcwkerpedrptfdylrsvledfftategqyqpqp
Sequence, based on observed residues (ATOM records): (download)
>3acjA (A:)
kpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaean
lmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiae
gmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtape
ainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeely
qlmrlcwkerpedrptfdylrsvledfftate