PDB entry 2zwf

View 2zwf on RCSB PDB site
Description: Crystal structure of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus obtained by soaking the deoxy-form crystal in dioxygen-saturated solution for 80 minutes
Class: oxidoreductase/metal transport
Keywords: tyrosinase, binary complex, type-3 copper, dioxygen, copper transfer, oxidoreductase-metal transport complex
Deposited on 2008-12-03, released 2009-12-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-08-31, with a file datestamp of 2011-08-26.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.173
AEROSPACI score: 0.69 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosinase
    Species: STREPTOMYCES CASTANEOGLOBISPORUS [TaxId:79261]
    Gene: TYRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83WS2 (Start-272)
      • conflict (122)
      • expression tag (273-276)
    Domains in SCOPe 2.08: d2zwfa1, d2zwfa2
  • Chain 'B':
    Compound: MelC
    Species: STREPTOMYCES CASTANEOGLOBISPORUS [TaxId:79261]
    Gene: ORF378
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83WS1
      • see remark 999 (97)
    Domains in SCOPe 2.08: d2zwfb_
  • Heterogens: CU, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zwfA (A:)
mtvrknqatltadekrrfvaavlelkrsgrydefvrthnefimsdtdsgertghrspsfl
pwhrrflldfeqalqsvdssvtlpywdwsadrtvraslwapdflggtgrstdgrvmdgpf
aastgnwpinvrvdsrtylrrslggsvaelptraevesvlaisaydlppynsasegfrnh
legwrgvnlhnrvhvwvggqmatgvspndpvfwlhhayvdklwaewqrrhpdsayvptgg
tpdvvdlnetmkpwntvrpadlldhtayytfdalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2zwfA (A:)
tvrknqatltadekrrfvaavlelkrsgrydefvrthnefimsdtdsgertghrspsflp
whrrflldfeqalqsvdssvtlpywdwsadrtvraslwapdflggtgrstdgrvmdgpfa
astgnwpinvrvdsrtylrrslggsvaelptraevesvlaisaydlppynsasegfrnhl
egwrgvnlhnrvhvwvggqmatgvspndpvfwlhhayvdklwaewqrrhpdsayvptggt
pdvvdlnetmkpwntvrpadlldhtayytfdalehh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zwfB (B:)
mpeitrrraltaaaavaatasaavtlaapaasaaghhepaapesfdevykgrriqgrpar
gaahhhehgggyevfvdgvqlhvmrnadgswisvvshfdpvptpraaaraavdelqgapl
lpfpanlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2zwfB (B:)
aapesfdevykgrriqgrpagyevfvdgvqlhvmrnadgswisvvshfdpvptpraaara
avdelqgapllp