PDB entry 2zkx

View 2zkx on RCSB PDB site
Description: Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121
Class: oxidoreductase
Keywords: oxidoreductase, human Cu-Zn superoxide dismutase, ALS, FALS, metal-binding, disease mutation, E.C.1.15.1.1, Amyotrophic lateral sclerosis, Antioxidant, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
Deposited on 2008-03-31, released 2009-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-04-04, with a file datestamp of 2012-03-30.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: 0.176
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (Start-158)
      • engineered (90)
    Domains in SCOPe 2.08: d2zkxa_
  • Chain 'B':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (Start-158)
      • engineered (90)
    Domains in SCOPe 2.08: d2zkxb_
  • Chain 'C':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441
      • engineered (90)
    Domains in SCOPe 2.08: d2zkxc_
  • Chain 'D':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441
      • engineered (90)
    Domains in SCOPe 2.08: d2zkxd_
  • Heterogens: CU1, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zkxA (A:)
gplgsmatkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdnt
agctsagphfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciig
rtlvvhekaddlgkggneestktgnagsrlacgvigiaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zkxA (A:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagctsa
gphfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlacgvigiaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zkxB (B:)
gplgsmatkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdnt
agctsagphfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciig
rtlvvhekaddlgkggneestktgnagsrlacgvigiaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zkxB (B:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagctsa
gphfnplsrkhggpkdeerhvgdlrnvtaddgvadvsiedsvislsgdhciigrtlvvhe
kaddlgkggneestktgnagsrlacgvigiaq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2zkxC (C:)
gplgsmatkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdnt
agctsagphfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciig
rtlvvhekaddlgkggneestktgnagsrlacgvigiaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zkxC (C:)
tkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagctsag
phfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciigrtlvvhe
kaddlgkggneestktgnagsrlacgvigia

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2zkxD (D:)
gplgsmatkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdnt
agctsagphfnplsrkhggpkdeerhvgdlrnvtadkdgvadvsiedsvislsgdhciig
rtlvvhekaddlgkggneestktgnagsrlacgvigiaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zkxD (D:)
tkavcvlkgdgpvqgiinfeqpvkvwgsikglteglhgfhvhefgdntagctsagphfnp
lgdlrnvtadkdgvadvsiedsvislsgdhciigrtlvvhekaddagsrlacgvigia