PDB entry 2zd1
View 2zd1 on RCSB PDB site
Description: Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor
Class: transferase, hydrolase/inhibitor
Keywords: P51/P66, HETERO DIMER, NNRTI, NONNUCLEOSIDE INHIBITOR, AIDS, HIV, R278474, RILPIVIRINE, DIARYLPYRIMIDINE, DAPY, DNA RECOMBINATION, RNA-DIRECTED DNA POLYMERASE, DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, MULTIFUNCTIONAL ENZYME, TRANSFERASE, HYDROLASE-INHIBITOR complex
Deposited on
2007-11-16, released
2008-02-12
The last revision prior to the SCOPe 2.02 freeze date was dated
2012-08-01, with a file datestamp of
2012-07-27.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.22
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Reverse transcriptase/ribonuclease H
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: gag-pol
Database cross-references and differences (RAF-indexed):
- Uniprot P03366 (2-End)
- expression tag (0-1)
- engineered (173-174)
- engineered (281)
- Chain 'B':
Compound: p51 RT
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: gag-pol
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2zd1b1 - Heterogens: SO4, T27, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2zd1B (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyq
Sequence, based on observed residues (ATOM records): (download)
>2zd1B (B:)
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglflwmgyelhpdkwtvqpivlpekdswtvnd
iqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhg
vyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkit
tesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq