PDB entry 2z7r

View 2z7r on RCSB PDB site
Description: Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine
Class: transferase
Keywords: protein kinase, cancer, kinase inhibitor, ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Phosphorylation, Polymorphism, Serine/threonine-protein kinase, Transferase
Deposited on 2007-08-28, released 2008-05-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.255
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosomal protein S6 kinase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS6KA1, RSK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2z7ra_
  • Heterogens: STU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2z7rA (A:)
qpskdegvlkeisithhvkagsekadpshfellkvlgqgsfgkvflvrkvtrpdsghlya
mkvlkkatlkvrdrvrtkmerdiladvnhpfvvklhyafqtegklylildflrggdlftr
lskevmfteedvkfylaelalgldhlhslgiiyrdlkpenilldeeghikltdfglskea
idhekkaysfcgtveymapevvnrqghshsadwwsygvlmfemltgslpfqgkdrketmt
lilkaklgmpqflsteaqsllralfkrnpanrlgsgpdgaeeikrhvfystidwnklyrr
eikppfkpavaqpddtfyfdt

    Sequence, based on observed residues (ATOM records): (download) 
    >2z7rA (A:)
gsekadpshfellkvlgqgsfgkvflvrkvtrpdsghlyamkvlkkatlkviladvnhpf
vvklhyafqtegklylildflrggdlftrlskevmfteedvkfylaelalgldhlhslgi
iyrdlkpenilldeeghikltdfglskegtveymapevvnrqghshsadwwsygvlmfem
ltgslpfqgkdrketmtlilkaklgmpqflsteaqsllralfkrnpanrlgsgpdgaeei
krhvfystidwnklyrreikppfkp