PDB entry 2yjr

View 2yjr on RCSB PDB site
Description: Structure of F1174L Mutant Anaplastic Lymphoma Kinase
Class: transferase
Keywords: transferase, crizotinib
Deposited on 2011-05-23, released 2012-06-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (104)
    Domains in SCOPe 2.08: d2yjra_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2yjrA (A:)
mahhhhhhdygipttenlyfqgsnpnycfagktssisdlkevprknitlirglghgafge
vyegqvsgmpndpsplqvavktlpevcseqdeldflmealiisklnhqnivrcigvslqs
lprfillelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrd
iaarnclltcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsk
tdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhq
pedrpnfaiilerieyctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >2yjrA (A:)
ktssisdlkevprknitlirglghgafgevyegqvsplqvavktlpevcseqdeldflme
aliisklnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslamldll
hvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmcamlpvkwmppeaf
megiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyri
mtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg