PDB entry 2xb6

View 2xb6 on RCSB PDB site
Description: revisited crystal structure of neurexin1beta-neuroligin4 complex
Class: cell adhesion
Keywords: alpha-beta-hydrolase fold, autism, conformational rearrangement, cell adhesion
Deposited on 2010-04-07, released 2010-06-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.205
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: neuroligin-4, x-linked
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N0W4 (12-End)
      • expression tag (11)
      • cloning artifact (529)
    Domains in SCOPe 2.06: d2xb6a1, d2xb6a2
  • Chain 'B':
    Compound: neuroligin-4, x-linked
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N0W4 (12-End)
      • expression tag (2-11)
      • cloning artifact (529)
    Domains in SCOPe 2.06: d2xb6b1, d2xb6b2
  • Chain 'C':
    Compound: Neurexin-1-beta
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2xb6c_
  • Chain 'D':
    Compound: Neurexin-1-beta
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2xb6d_
  • Heterogens: NAG, EDO, CL, MES, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xb6A (A:)
dykddddklaaaqypvvntnygkirglrtplpneilgpveqylgvpyaspptgerrfqpp
eppsswtgirnttqfaavcpqhldersllhdmlpiwftanldtlmtyvqdqnedclylni
yvpteddihdqnskkpvmvyihggsymegtgnmidgsilasygnvivitinyrlgilgfl
stgdqaakgnyglldqiqalrwieenvgafggdpkrvtifgsgagascvslltlshyseg
lfqkaiiqsgtalsswavnyqpakytriladkvgcnmldttdmveclrnknykeliqqti
tpatyhiafgpvidgdvipddpqilmeqgeflnydimlgvnqgeglkfvdgivdnedgvt
pndfdfsvsnfvdnlygypegkdtlretikfmytdwadkenpetrrktlvalftdhqwva
pavatadlhaqygsptyfyafyhhcqsemkpswadsahgdevpyvfgipmigptelfscn
fskndvmlsavvmtywtnfaktgdpnqpvpqdtkfihtkpnrfeevawsrynpkdqlylh
iglkprvrdhyratkvafwlelvphlhnlneifqyvstttkvpppdmt

    Sequence, based on observed residues (ATOM records): (download) 
    >2xb6A (A:)
aqypvvntnygkirglrtpllgpveqylgvpyaspptgerrfqppeppsswtgirnttqf
aavcpqhldersllhdmlpiwftanldtlmtyvqdqnedclylniyvpteskkpvmvyih
ggsymegtgnmidgsilasygnvivitinyrlgilgflstgdqaakgnyglldqiqalrw
ieenvgafggdpkrvtifgsgagascvslltlshyseglfqkaiiqsgtalsswavnyqp
akytriladkvgcnmldttdmveclrnknykeliqqtitpatyhiafgpvidgdvipddp
qilmeqgeflnydimlgvnqgeglkfvdgivdnedgvtpndfdfsvsnfvdnlygypegk
dtlretikfmytdwadkenpetrrktlvalftdhqwvapavatadlhaqygsptyfyafy
hhcqsemkpswadsahgdevpyvfgipmigptelfscnfskndvmlsavvmtywtnfakt
gdpnqpvvawsrynpkdqlylhiglkprvrdhyratkvafwlelvphlh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xb6B (B:)
dykddddklaaaqypvvntnygkirglrtplpneilgpveqylgvpyaspptgerrfqpp
eppsswtgirnttqfaavcpqhldersllhdmlpiwftanldtlmtyvqdqnedclylni
yvpteddihdqnskkpvmvyihggsymegtgnmidgsilasygnvivitinyrlgilgfl
stgdqaakgnyglldqiqalrwieenvgafggdpkrvtifgsgagascvslltlshyseg
lfqkaiiqsgtalsswavnyqpakytriladkvgcnmldttdmveclrnknykeliqqti
tpatyhiafgpvidgdvipddpqilmeqgeflnydimlgvnqgeglkfvdgivdnedgvt
pndfdfsvsnfvdnlygypegkdtlretikfmytdwadkenpetrrktlvalftdhqwva
pavatadlhaqygsptyfyafyhhcqsemkpswadsahgdevpyvfgipmigptelfscn
fskndvmlsavvmtywtnfaktgdpnqpvpqdtkfihtkpnrfeevawsrynpkdqlylh
iglkprvrdhyratkvafwlelvphlhnlneifqyvstttkvpppdmt

    Sequence, based on observed residues (ATOM records): (download) 
    >2xb6B (B:)
kddddklaaaqypvvntnygkirglrtplpneilgpveqylgvpyaspptgerrfqppep
psswtgirnttqfaavcpqhldersllhdmlpiwftanldtlmtyvqdqnedclylniyv
ptekkpvmvyihggsymegtgnmidgsilasygnvivitinyrlgilgflstgdqaakgn
yglldqiqalrwieenvgafggdpkrvtifgsgagascvslltlshyseglfqkaiiqsg
talsswavnyqpakytriladkvgcnmldttdmveclrnknykeliqqtitpatyhiafg
pvidgdvipddpqilmeqgeflnydimlgvnqgeglkfvdgivdnedgvtpndfdfsvsn
fvdnlygypegkdtlretikfmytdwadkenpetrrktlvalftdhqwvapavatadlha
qygsptyfyafyhhcqsemkpswadsahgdevpyvfgipmigptelfscnfskndvmlsa
vvmtywtnfaktgdpnqpvvawsrynpkdqlylhiglkprvrdhyratkvafwlelvphl
h

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xb6C (C:)
gghagttyifskgggqitykwppndrpstradrlaigfstvqkeavlvrvdsssglgdyl
elhihqgkigvkfnvgtddiaieesnaiindgkyhvvrftrsggnatlqvdswpvieryp
agrqltifnsqatiiiggkeqgqpfqgqlsglyynglkvlnmaaendaniaivgnvrlv

    Sequence, based on observed residues (ATOM records): (download) 
    >2xb6C (C:)
hagttyifskgggqitykwppndrpstradrlaigfstvqkeavlvrvdsssglgdylel
hihqgkigvkfnvgtddiaieesnaiindgkyhvvrftrsggnatlqvdswpvierypag
rqltifnsqatiiiggkeqgqpfqgqlsglyynglkvlnmaaendaniaivgnvrlv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2xb6D (D:)
gghagttyifskgggqitykwppndrpstradrlaigfstvqkeavlvrvdsssglgdyl
elhihqgkigvkfnvgtddiaieesnaiindgkyhvvrftrsggnatlqvdswpvieryp
agrqltifnsqatiiiggkeqgqpfqgqlsglyynglkvlnmaaendaniaivgnvrlv

    Sequence, based on observed residues (ATOM records): (download) 
    >2xb6D (D:)
hagttyifskgggqitykwppndrpstradrlaigfstvqkeavlvrvdsssglgdylel
hihqgkigvkfnvgtddiaieesnaiindgkyhvvrftrsggnatlqvdswpvierypag
rqltifnsqatiiiggkeqgqpfqgqlsglyynglkvlnmaaendaniaivgnvrlv