PDB entry 2x8b

View 2x8b on RCSB PDB site
Description: crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II
Class: hydrolase/toxin
Keywords: hydrolase-toxin complex, cell junction, hydrolase, gpi-anchor, neurotransmitter degradation, tabun, aging, serine esterase, blood group antigen
Deposited on 2010-03-08, released 2010-04-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-06, with a file datestamp of 2011-07-01.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.1867
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acethylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2x8ba_
  • Chain 'B':
    Compound: fasciculin-2
    Species: Dendroaspis angusticeps [TaxId:8618]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2x8bb_
  • Heterogens: CL, SO4, UNX, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2x8bA (A:)
    egredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvv
    dattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiyg
    ggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlal
    qwvqenvaafggdptsvtlfgexagaasvgmhllsppsrglfhravlqsgapngpwatvg
    mgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfv
    pvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefl
    agvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaa
    qgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmryw
    anfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkll
    satdtldeaerqwkaefhrwssymvhwknqfdhyskqdrcsdl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2x8bA (A:)
    daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
    fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
    sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
    envaafggdptsvtlfgexagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
    rrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdflsd
    tpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpqv
    sdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayvf
    ehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdpn
    eprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsatdtld
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2x8bB (B:)
    tmcyshtttsrailtncgenscyrksrrhppkmvlgrgcgcppgddnlevkcctspdkcn
    y