PDB entry 2x4u

View 2x4u on RCSB PDB site
Description: crystal structure of MHC class I hla-a2.1 bound to hiv-1 peptide rt468-476
Class: immune system
Keywords: glycoprotein, immune system, transmembrane, phosphoprotein, immune response, secreted, glycation, amyloidosis, immunoglobulin domain, host-virus interaction, amyloid, membrane, photocleavable peptide, pyrrolidone carboxylic acid, envelope protein, disease mutation
Deposited on 2010-02-02, released 2010-03-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-03-02, with a file datestamp of 2010-02-26.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.1787
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X4U (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.06: d2x4ub1, d2x4ub2
  • Chain 'C':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X4U (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.06: d2x4ue1, d2x4ue2
  • Chain 'F':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2x4uB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2x4uE (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.