PDB entry 2x4u

View 2x4u on RCSB PDB site
Description: Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476
Class: immune system
Keywords: glycoprotein, immune system, transmembrane, phosphoprotein, immune response, secreted, glycation, amyloidosis, immunoglobulin domain, host-virus interaction, amyloid, membrane, photocleavable peptide, pyrrolidone carboxylic acid, envelope protein, disease mutation
Deposited on 2010-02-02, released 2010-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2X4U (0-0)
  • Uniprot P61769 (1-99)
  Domains in SCOPe 2.08: d2x4ub1, d2x4ub2
• Chain 'C':
  Compound: Reverse transcriptase/ribonuclease H
  Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-8)
• Chain 'D':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2X4U (0-0)
  • Uniprot P61769 (1-99)
  Domains in SCOPe 2.08: d2x4ue1, d2x4ue2
• Chain 'F':
  Compound: Reverse transcriptase/ribonuclease H
  Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-8)
• Heterogens: GOL, MES, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2x4uB (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2x4uE (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.