PDB entry 2x4d

View 2x4d on RCSB PDB site
Description: Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP
Class: hydrolase
Keywords: hydrolase
Deposited on 2010-01-29, released 2010-03-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X4D (0-0)
      • see remark 999 (94)
      • engineered mutation (160-161)
    • Uniprot Q9H008 (1-End)
    Domains in SCOPe 2.08: d2x4da_
  • Chain 'B':
    Compound: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X4D
      • see remark 999 (94)
      • engineered mutation (160-161)
    • Uniprot Q9H008
    Domains in SCOPe 2.08: d2x4db_
  • Heterogens: POP, MG, EPE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x4dA (A:)
smapwgkrlagvrgvlldisgvlydsgagggtaiagsveavarlkrsrlkvrfctnesaa
sraelvgqlqrlgfdiseqevtapapaacqilkerglrpyllihdgvrsefdqidtsnpn
cvviadagesfsyqnmnnafqvlmelekpvlislgkgryyaatsglmldvgpymkaleya
cgikaevvgkpspeffksalqaigveahqavmigddivgdvggaqrcgmralqvrtgkfr
psdehhpevkadgyvdnlaeavdlllqhadk

    Sequence, based on observed residues (ATOM records): (download) 
    >2x4dA (A:)
smapwgkrlagvrgvlldisgvlydsgagggtaiagsveavarlkrsrlkvrfctnesaa
sraelvgqlqrlgfdiseqevtapapaacqilkerglrpyllihdgvrsefdqidtsnpn
cvviadagesfsyqnmnnafqvlmelekpvlislgkgryyaatsglmldvgpymkaleya
cgikaevvgkpspeffksalqaigveahqavmigddivgdvggaqrcgmralqvrtgkfr
psdehhpevkadgyvdnlaeavdlllqhad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2x4dB (B:)
smapwgkrlagvrgvlldisgvlydsgagggtaiagsveavarlkrsrlkvrfctnesaa
sraelvgqlqrlgfdiseqevtapapaacqilkerglrpyllihdgvrsefdqidtsnpn
cvviadagesfsyqnmnnafqvlmelekpvlislgkgryyaatsglmldvgpymkaleya
cgikaevvgkpspeffksalqaigveahqavmigddivgdvggaqrcgmralqvrtgkfr
psdehhpevkadgyvdnlaeavdlllqhadk

    Sequence, based on observed residues (ATOM records): (download) 
    >2x4dB (B:)
lldisgvlydsggtaiagsveavfctnesaasraelvgqltapapaacqilkerglrpyl
lihdgvrsefdnpncvviadagesfsyqnmnnafqvlmelekpvlislgkgryyaaglml
dvgpymkaleyacgikaevvgkpspeffksalqaigveahqavmigddivgdvggaqrcg
mralqvrtgkfrpsdehhpevkadgyvdnlaea