PDB entry 2wyg
View 2wyg on RCSB PDB site
Description: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs
Class: blood clotting
Keywords: blood clotting, serine protease, egf-like domain, blood coagulation, hydrolase, hydroxylation, zymogen
Deposited on
2009-11-16, released
2010-12-01
The last revision prior to the SCOPe 2.07 freeze date was dated
2010-12-01, with a file datestamp of
2010-11-26.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: 0.19759
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: activated factor xa heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2wyga_ - Chain 'B':
Compound: factor x light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2wygb_ - Heterogens: 461, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wygA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk
Sequence, based on observed residues (ATOM records): (download)
>2wygA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
avhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtqktgi
vsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacqgdsg
gphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2wygB (B:)
eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
ptgpypcgkqtler
Sequence, based on observed residues (ATOM records): (download)
>2wygB (B:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl