PDB entry 2wip
View 2wip on RCSB PDB site
Description: structure of cdk2-cyclin a complexed with 8-anilino-1-methyl-4,5-dihydro- 1h-pyrazolo[4,3-h] quinazoline-3-carboxylic acid
Class: transferase
Keywords: cell cycle, ATP-binding, transferase, phosphorylation, nucleotide-binding, serine/threonine-protein 2 kinase, serine/threonine-protein kinase, cell division, phosphoprotein, protein kinase, kinase, cyclin, nucleus, mitosis
Deposited on
2009-05-14, released
2009-07-28
The last revision prior to the SCOPe 2.02 freeze date was dated
2012-10-10, with a file datestamp of
2012-10-05.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.221
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WIP
- Uniprot P24941 (5-302)
Domains in SCOPe 2.02: d2wipa_ - Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WIP
- Uniprot P20248 (Start-264)
- Chain 'C':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WIP
- Uniprot P24941 (5-End)
Domains in SCOPe 2.02: d2wipc_ - Chain 'D':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WIP
- Uniprot P20248 (Start-264)
- Heterogens: P49, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wipA (A:)
gplvdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisll
kelnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgl
afchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeill
gckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpd
ykpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph
lrlerphrd
Sequence, based on observed residues (ATOM records): (download)
>2wipA (A:)
plvdmenfqkvekigvvykarnkltgevvalkkirldtetegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2wipC (C:)
gplvdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisll
kelnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgl
afchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeill
gckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpd
ykpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph
lrlerphrd
Sequence, based on observed residues (ATOM records): (download)
>2wipC (C:)
dmenfqkvekigvvykarnkltgevvalkkirldtetegvpstaireisllkelnhpniv
klldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvl
hrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystav
diwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwa
rqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
- Chain 'D':
No sequence available.