PDB entry 2wio

View 2wio on RCSB PDB site
Description: structure of the histidine tagged, open cytochrome p450 eryk from s. erythraea
Class: oxidoreductase
Keywords: substrate specificity, antibiotic biosynthesis, metal-binding, oxidoreductase, cytochrome p450, iron, heme, erythromicyn, monooxygenase
Deposited on 2009-05-14, released 2009-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-10-20, with a file datestamp of 2009-10-16.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.18587
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: erythromycin b/d c-12 hydroxylase
    Species: Saccharopolyspora erythraea [TaxId:1836]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WIO
      • conflict (363)
    • Uniprot P48635 (Start-430)
    Domains in SCOPe 2.08: d2wioa_
  • Heterogens: HEM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wioA (A:)
mgsshhhhhhssglvprgshmfadvettccarrtlttidevpgmadetalldwlgtmrek
qpvwqdrygvwhvfrhadvqtvlrdtatfssdptrviegasptpgmiheidppehralrk
vvssaftprtisdleprirdvtrslladagesfdlvdvlafplpvtivaellglppmdhe
qfgdwsgalvdiqmddptdpalaeriadvlnpltaylkarcaerradpgddlisrlvlae
vdgralddeeaanfstalllaghitttvllgnivrtldehpahwdaaaedpgripaivee
vlryrppfpqmqrtttkatevagvpipadvmvntwvlsanrdsdahddpdrfdpsrksgg
aaqlsfghgvhfclgaplarlenrvaleeiiarfgrltvdrdderlrhfeqivlgtrhlp
vlagssprqsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2wioA (A:)
devpgmadetalldwlgtmrekqpvwqdrygvwhvfrhadvqtvlrdtatfssdptrvie
gasptpgmiheidppehralrkvvssaftprtisdleprirdvtrslladagesfdlvdv
lafplpvtivaellglppmdheqfgdwsgalvdiqmddptdpalaeriadvlnpltaylk
arcaerradpgddlisrlvlaevdgralddeeaanfstalllaghitttvllgnivrtld
ehpahwdaaaedpgripaiveevlryrppfpqmqrtttkatevagvpipadvmvntwvls
anrdsdahddpdrfdpsrksggaaqlsfghgvhfclgaplarlenrvaleeiiarfgrlt
vdrdderlrhfeqivlgtrhlpvlagssprqsa