PDB entry 2wi3
View 2wi3 on RCSB PDB site
Description: orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
Class: chaperone
Keywords: chaperone, heat shock, stress response, nucleotide-binding
Deposited on
2009-05-08, released
2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-09-29, with a file datestamp of
2010-09-24.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.19992
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heat shock protein, hsp 90-alpha
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2wi3a_ - Heterogens: MG, ZZ3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wi3A (A:)
mpeetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkir
yesltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafme
alqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepm
grgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae
Sequence, based on observed residues (ATOM records): (download)
>2wi3A (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfvek