PDB entry 2wd2
View 2wd2 on RCSB PDB site
Description: a chimeric microtubule disruptor with efficacy on a taxane resistant cell line
Class: lyase
Keywords: disease mutation, lyase, cancer, human carbonic anhydrase inhibitors, metal-binding
Deposited on
2009-03-19, released
2010-03-31
The last revision prior to the SCOPe 2.06 freeze date was dated
2010-04-28, with a file datestamp of
2010-04-23.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: 0.206
AEROSPACI score: 0.61
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Carbonic anhydrase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2wd2a_ - Heterogens: ZN, MS5, FMT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wd2A (A:)
shhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslriln
nghafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlv
hwntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdpr
gllpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmv
dnwrpaqplknrqikasfk
Sequence, based on observed residues (ATOM records): (download)
>2wd2A (A:)
hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
ghafnvefddavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvhwntk
ygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgllpe
sldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvdnwrp
aqplknrqikasfk