PDB entry 2wd2

View 2wd2 on RCSB PDB site
Description: a chimeric microtubule disruptor with efficacy on a taxane resistant cell line
Class: lyase
Keywords: disease mutation, lyase, cancer, human carbonic anhydrase inhibitors, metal-binding
Deposited on 2009-03-19, released 2010-03-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-04-28, with a file datestamp of 2010-04-23.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: 0.206
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2wd2a_
  • Heterogens: ZN, MS5, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wd2A (A:)
    shhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslriln
    nghafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlv
    hwntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdpr
    gllpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmv
    dnwrpaqplknrqikasfk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wd2A (A:)
    hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
    ghafnvefddavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvhwntk
    ygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgllpe
    sldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvdnwrp
    aqplknrqikasfk