PDB entry 2wa6

View 2wa6 on RCSB PDB site
Description: structure of the w148r mutant of human filamin b actin binding domain at 1.95 angstroms resolution
Class: structural protein
Keywords: disease mutation, skeletal dysplasia, structural protein, actin-crosslinking, myogenesis, cytoskeleton, actin-binding, calponin homology domain, phosphoprotein, differentiation, atelosteogenesis, mutant, filamin, dwarfism, ch domain, developmental protein
Deposited on 2009-02-03, released 2009-06-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.19734
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Filamin-B
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WA6
      • engineered mutation (150)
    • Uniprot O75369
    Domains in SCOPe 2.05: d2wa6a1, d2wa6a2
  • Heterogens: CO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wa6A (A:)
gamapvtekdlaedapwkkiqqntftrwcnehlkcvnkrignlqtdlsdglrliallevl
sqkrmyrkyhqrptfrqmqlenvsvalefldresiklvsidskaivdgnlklilglvwtl
ilhysismpvwedegdddakkqtpkqrllgriqnkipylpitnfnqnwqdgkalgalvds
capglcpdweswdpqkpvdnareamqqaddwlgvpqvitpeeiihpdvdehsvmtylsqf
pkakl

    Sequence, based on observed residues (ATOM records): (download) 
    >2wa6A (A:)
laedapwkkiqqntftrwcnehlkcvnkrignlqtdlsdglrliallevlsqkrmyrkyh
qrptfrqmqlenvsvalefldresiklvsidskaivdgnlklilglvwtlilhysismpv
wedekkqtpkqrllgriqnkipylpitnfnqnwqdgkalgalvdscapglcpdweswdpq
kpvdnareamqqaddwlgvpqvitpeeiihpdvdehsvmtylsqfpk