PDB entry 2w2n

View 2w2n on RCSB PDB site
Description: wt pcsk9-deltac bound to egf-a h306y mutant of ldlr
Class: hydrolase/receptor
Keywords: hydrolase-receptor complex, pcsk9, ldlr, proprotein convertase, low-density lipoprotein receptor, egf, cardiovascular disease, familial hypercholesterolemia, lipid metabolism, serine protease, hydrolase, lipid transport, steroid metabolism, receptor
Deposited on 2008-11-03, released 2008-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.21531
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7 (0-End)
    • PDB 2W2N
    Domains in SCOPe 2.08: d2w2na_
  • Chain 'E':
    Compound: low-density lipoprotein receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W2N (Start-26)
      • engineered mutation (40)
    • Uniprot P01130 (27-End)
    Domains in SCOPe 2.08: d2w2ne1, d2w2ne2
  • Chain 'P':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W2N
    • Uniprot Q8NBP7 (Start-113)
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w2nA (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgaa
gtaaashhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2w2nA (A:)
sipwnleritpprlvevylldtsiqsdhreiegrvmvtdfenvpeedskcdshgthlagv
vsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggy
srvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgt
nfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltlaelrq
rlihfsakdvineawfpedqrvltpnlvaalpp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2w2nE (E:)
mkhhhhhhpmsdydipttenlyfqgamgtnecldnnggcsyvcndlkigyeclcpdgfql
vaqrrcedidecqdpdtcsqlcvnleggykcqceegfqldphtkack

    Sequence, based on observed residues (ATOM records): (download) 
    >2w2nE (E:)
nlyfqgamgtnecldnnggcsyvcndlkigyeclcpdgfqlvaqrrced

  • Chain 'P':
    No sequence available.