PDB entry 2w1h

View 2w1h on RCSB PDB site
Description: fragment-based discovery of the pyrazol-4-yl urea (at9283), a multi-targeted kinase inhibitor with potent aurora kinase activity
Class: transferase
Keywords: structure based drug design, kinase, mitosis, cell cycle, transferase, serine/threonine-protein kinase, ATP-binding, polymorphism, cell division, phosphoprotein, fragment screening, nucleotide-binding
Deposited on 2008-10-17, released 2009-01-27
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-01-27, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.263
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2w1ha_
  • Heterogens: L0H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w1hA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >2w1hA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirtegvpstaireisllkelnhpniv
klldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvl
hrdlkpqnllintegaikladfglarafvtlwyrapeillgckyystavdiwslgcifae
mvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppl
dedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl