PDB entry 2w0x

View 2w0x on RCSB PDB site
Description: factor inhibiting hif-1 alpha with pyridine 2,4 dicarboxylic acid
Class: oxidoreductase
Keywords: hydroxylase, dioxygenase, transcription, oxidoreductase, transcription activator/inhibitor, hypoxia
Deposited on 2008-10-10, released 2009-11-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-09-29, with a file datestamp of 2010-09-24.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: 0.213
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxia-inducible factor 1 alpha inhibitor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2w0xa_
  • Heterogens: FE2, PD2, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w0xA (A:)
maataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelienee
pvvltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnr
eemkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwg
qltsnllligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqs
qvdfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykga
ptpkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0xA (A:)
avasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdt
nlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhe
fveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnll
ligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnp
dyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrie
yplkahqkvaimrniekmlgealgnpqevgpllntmikgryn