PDB entry 2w0j

View 2w0j on RCSB PDB site
Description: crystal structure of chk2 in complex with nsc 109555, a specific inhibitor
Class: transferase
Keywords: chk2 inhibitor, oncology, kinase, structure-assisted drug design, transferase, nucleotide-binding, li-fraumeni syndrome, serine/threonine-protein kinase
Deposited on 2008-08-18, released 2009-02-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-10, with a file datestamp of 2009-02-06.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.217
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase chk2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W0J
    • Uniprot O96017 (1-End)
    Domains in SCOPe 2.06: d2w0ja_
  • Heterogens: ZAT, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w0jA (A:)
msvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpal
nveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyf
yqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtp
tylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfi
pevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestal
pqvlaqpstsrkrpregeaegae

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0jA (A:)
svypkalrdeyimsktlgsgevklaferktckkvaikiisknveteieilkklnhpciik
iknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihrd
lkpenvllssqeedclikitdfghskiltslmrtlcgtptylapevlvsvgtagynravd
cwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkllvv
dpkarftteealrhpwlqdedmkrkfqdllseenetalpq