PDB entry 2w09

View 2w09 on RCSB PDB site
Description: cyp51 of m. tuberculosis bound to an inhibitor cis-4-methyl-n-[(1s)-3-(methylsulfanyl)-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide
Class: oxidoreductase
Keywords: steroid biosynthesis, protein-inhibitor complex, metal-binding, oxidoreductase, lipid synthesis, nadp, iron, heme, cytoplasm, monooxygenase, sterol biosynthesis
Deposited on 2008-08-12, released 2009-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.57 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 51
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A512
      • engineered mutation (36)
      • engineered mutation (441)
    • PDB 2W09
    Domains in SCOPe 2.08: d2w09a_
  • Heterogens: HEM, CM9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w09A (A:)
msavalprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshane
fffragdddldqakaypfmtpifgegvvfdasperrkemlhnaalrgeqmkghaatiedq
vrrmiadwgeageidlldffaeltiytssacligkkfrdqldgrfaklyhelergtdpla
yvdpylpiesfrrrdearnglvalvadimngrianpptdksdrdmldvliavkaetgtpr
fsadeitgmfismmfaghhtssgtaswtlielmrhrdayaavideldelygdgrsvsfha
lrqipqlenvlketlrlhppliilmrvakgefevqghrihegdlvaaspaisnripedfp
dphdfvparyeqprqedllnrwtwipfgagrhrcvgaafaimqikaifsvllreyefema
qppesyrndhskmvvqlaqpaavryrrrtgvhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2w09A (A:)
valprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshanefff
ragdddldqakaypfmtpifghnaalrgeqmkghaatiedqvrrmiadwgeageidlldf
faeltiytssacligkkfrdqldgrfaklyhelergtdplayvdpylpiesfrrrdearn
glvalvadimngrianprdmldvliavkatprfsadeitgmfismmfaghhtssgtaswt
lielmrhrdayaavideldelygdgrsvsfhalrqipqlenvlketlrlhppliilmrva
kgefevqghrihegdlvaaspaisnripedfpdphdfvparyeqprqedllnrwtwipfg
agrhrcvgaafaimqikaifsvllreyefemaqppesyrndhskmvvqlaqpaavryrrr
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