PDB entry 2vze

View 2vze on RCSB PDB site
Description: Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP
Class: ligase
Keywords: ligase, metal-binding, transit peptide, lipid metabolism, nucleotide-binding, ATP-binding, adenylate-forming enzyme, fatty acid metabolism, fatty acid-coa ligase
Deposited on 2008-07-31, released 2008-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acyl-coenzyme a synthetase acsm2a, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
      • conflict (455)
    Domains in SCOPe 2.08: d2vzea_
  • Chain 'B':
    Compound: acyl-coenzyme a synthetase acsm2a, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
      • conflict (455)
    Domains in SCOPe 2.08: d2vzeb_
  • Chain 'C':
    Compound: acyl-coenzyme a synthetase acsm2a, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
      • conflict (455)
    Domains in SCOPe 2.08: d2vzec_
  • Heterogens: AMP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vzeA (A:)
    mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
    alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
    raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
    cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
    wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
    mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
    ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
    dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
    vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
    lnlpktvtgkiqraklrdkewkmsgkaraq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vzeA (A:)
    hqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaanv
    lsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskaka
    ivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqeas
    aiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmep
    walgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvt
    vgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiid
    dkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyf
    qfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfl
    shdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2vzeB (B:)
    mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
    alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
    raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
    cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
    wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
    mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
    ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
    dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
    vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
    lnlpktvtgkiqraklrdkewkmsgkaraq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vzeB (B:)
    hqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaanv
    lsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskaka
    ivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqeas
    aiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmep
    walgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvt
    vgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiid
    dkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyf
    qfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfl
    shdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2vzeC (C:)
    mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
    alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
    raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
    cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
    wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
    mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
    ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
    dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
    vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
    lnlpktvtgkiqraklrdkewkmsgkaraq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vzeC (C:)
    qwghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqa
    anvlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmsk
    akaivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsq
    easaiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcsl
    mepwalgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqn
    cvtvgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvq
    iiddkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikded
    gyfqfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlas
    qflshdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk