PDB entry 2vu3
View 2vu3 on RCSB PDB site
Description: identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.
Class: transferase
Keywords: transferase, mitosis, cell cycle, serine/threonine protein kinase
Deposited on
2008-05-20, released
2008-08-05
The last revision prior to the SCOPe 2.04 freeze date was dated
2010-11-03, with a file datestamp of
2010-10-29.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.2046
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d2vu3a_ - Heterogens: LZE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vu3A (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
Sequence, based on observed residues (ATOM records): (download)
>2vu3A (A:)
menfqkvekigegtygvvykarnkltgevvalkkirltaireisllkelnhpnivklldv
ihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlk
pqnllintegaikladfgfgvpvrtythevvtlwyrapeillgckyystavdiwslgcif
aemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvp
pldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl