PDB entry 2vlk

View 2vlk on RCSB PDB site
Description: the structural dynamics and energetics of an immunodominant T-cell receptor are programmed by its vbeta domain
Class: immune system
Keywords: immune system, glycoprotein, transmembrane, immune system-receptor-complex, immunoglobulin domain, host-virus interaction, pyrrolidone carboxylic acid, immune response, immunodominance, disease mutation, membrane, secreted, receptor, glycation, tcr, flu, MHC, MHC I, T-cell, complex
Deposited on 2008-01-15, released 2008-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.221
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vlka1, d2vlka2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLK (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.08: d2vlkb2, d2vlkb3
  • Chain 'C':
    Compound: flu matrix peptide
    Species: UNIDENTIFIED INFLUENZA VIRUS, synthetic [TaxId:11309]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLK (0-8)
  • Chain 'D':
    Compound: jm22 tcr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLK
  • Chain 'E':
    Compound: jm22 tcr beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLK (Start-243)
    Domains in SCOPe 2.08: d2vlke1, d2vlke2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vlkA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vlkB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2vlkE (E:)
mvdggitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkg
diaegysvsrekkesfpltvtsaqknptafylcasssrssyeqyfgpgtrltvtedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad

    Sequence, based on observed residues (ATOM records): (download) 
    >2vlkE (E:)
gitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkgdiae
gysvsrekkesfpltvtsaqknptafylcasssrssyeqyfgpgtrltvtedlknvfppe
vavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpaln
dsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad