PDB entry 2vh6

View 2vh6 on RCSB PDB site
Description: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs
Class: hydrolase
Keywords: serine protease, egf-like domain, blood coagulation, polymorphism, glycoprotein, hydroxylation, gamma-carboxyglutamic acid, calcium, zymogen, complex, protease, hydrolase, cleavage on pair of basic residues
Deposited on 2007-11-19, released 2008-12-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-03, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.19906
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2vh6a_
  • Chain 'B':
    Compound: activated factor xa light chain
    Species: Homo sapiens [TaxId:9606]
    Domains in SCOPe 2.06: d2vh6b_
  • Heterogens: GSV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vh6A (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    kshapevitssplk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vh6A (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qegeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtq
    ktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacq
    gdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2vh6B (B:)
    eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
    geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
    ptgpypcgkqtler
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vh6B (B:)
    trklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle