PDB entry 2vgi

View 2vgi on RCSB PDB site
Description: human erythrocyte pyruvate kinase: r486w mutant
Class: transferase
Keywords: glycolysis, transferase
Deposited on 2007-11-13, released 2007-11-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: 0.258
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (439)
    Domains in SCOPe 2.05: d2vgia1, d2vgia2, d2vgia3
  • Chain 'B':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (439)
    Domains in SCOPe 2.05: d2vgib1, d2vgib2, d2vgib3
  • Chain 'C':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (439)
    Domains in SCOPe 2.05: d2vgic1, d2vgic2, d2vgic3
  • Chain 'D':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (439)
    Domains in SCOPe 2.05: d2vgid1, d2vgid2, d2vgid3
  • Heterogens: FBP, PGA, K, MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vgiA (A:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgiA (A:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaa
vraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmm
igrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpve
avkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltt
tgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfg
iesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vgiB (B:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgiB (B:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgivlvtantvdy
pniviyiddglislvvvtvenggvkgvnlplpglseqdvrdlrfgvehgvdivfasfvrk
asdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvf
laqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetak
gnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaa
iivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvd
rrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vgiC (C:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgiC (C:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgadlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavr
aalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmig
rcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveav
kmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttg
rsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgie
sgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vgiD (D:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgiD (D:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilesevelvkg
sqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtqv
enggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraa
lgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrc
nlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkm
qhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgrs
aqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesg
klrgflrvgdlvivvtgwrpgsgytnimrvlsi