PDB entry 2vgb

View 2vgb on RCSB PDB site
Description: human erythrocyte pyruvate kinase
Class: transferase
Keywords: metal-binding, phosphorylation, pyruvate kinase in the active r-state, kinase, pyruvate, magnesium, glycolysis, transferase, disease mutation
Deposited on 2007-11-12, released 2007-11-20
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: 0.229
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2vgba1, d2vgba2, d2vgba3
  • Chain 'B':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2vgbb1, d2vgbb2, d2vgbb3
  • Chain 'C':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2vgbc1, d2vgbc2, d2vgbc3
  • Chain 'D':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2vgbd1, d2vgbd2, d2vgbd3
  • Heterogens: FBP, PGA, K, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vgbA (A:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgbA (A:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaa
vraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmm
igrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpve
avkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltt
tgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfg
iesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vgbB (B:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgbB (B:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgivelvkgsqvl
vtantvwvdypnivrvvpvggriyiddglislvvvtqvenggvlgsrkgvnlpgaqvdlp
glseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkr
fdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkpr
ptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfeelr
raaplsrdptevtaigaveaafkccaaaiivltttgrsaqllsryrpraaviavtrsaqa
arqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgs
gytnimrvlsi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vgbC (C:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgbC (C:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaa
vraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmm
igrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpve
avkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltt
tgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfg
iesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vgbD (D:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vgbD (D:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgiesevelvkgs
qvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtqve
nggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraal
gpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcn
lagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmq
haiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgrsa
qllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgk
lrgflrvgdlvivvtgwrpgsgytnimrvlsi