PDB entry 2vg5

View 2vg5 on RCSB PDB site
Description: crystal structures of hiv-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
Class: transferase
Keywords: DNA-directed DNA polymerase, thiocarbamates, phosphorylation, DNA integration, magnesium, zinc-finger, RNA-binding, transferase, lipoprotein, core protein, endonuclease, metal-binding, zinc, aids, hiv-1, virion, nucleus, membrane, aspartyl protease, capsid maturation, multifunctional enzyme, RNA-directed DNA polymerase, reverse transcriptase, nucleotidyltransferase, DNA recombination, viral nucleoprotein, protease, nuclease, myristate, hydrolase, cytoplasm, non-nucleoside reverse transcriptase inhibitors
Deposited on 2007-11-08, released 2007-12-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.24
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2vg5a1, d2vg5a2
  • Chain 'B':
    Compound: p51 RT
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Domains in SCOPe 2.05: d2vg5b_
  • Heterogens: NNC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vg5A (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagir

    Sequence, based on observed residues (ATOM records): (download) 
    >2vg5A (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylal
qdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggne
qvdklvsagir

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vg5B (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyq

    Sequence, based on observed residues (ATOM records): (download) 
    >2vg5B (B:)
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglmgyelhpdkwtvqpivlpekdswtvndiqk
lvgklnwasqiypgikvrqlckltkalteviplteeaelelaenreilkepvhgvyydps
kdliaeiqkqgqgqwtyqiyqepfknlktgkyahtndvkqlteavqkittesiviwgktp
kfklpiqketwetwwteywqatwipewefvntpplvklwyq