PDB entry 2uzi

View 2uzi on RCSB PDB site
Description: crystal structure of hras(g12v) - anti-ras fv complex
Class: signaling protein/immune system
Keywords: signal transduction, immunoglobulin domain, membrane, antibody, oncogene, palmitate, intrabody, disease mutation, nucleotide-binding, proto-oncogene, cancer therapy, golgi apparatus, prenylation, methylation, lipoprotein, GTP- binding, signaling protein/immune system
Deposited on 2007-04-27, released 2007-06-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.198
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: anti-ras fv heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZI (3-106)
    Domains in SCOPe 2.06: d2uzih_
  • Chain 'L':
    Compound: anti-ras fv light chain
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Domains in SCOPe 2.06: d2uzil_
  • Chain 'R':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (0-165)
      • engineered mutation (11)
    Domains in SCOPe 2.06: d2uzir_
  • Heterogens: ZN, GTP, MG, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uziH (H:)
    evqllesggglvqpggslrlscaasgftfstfsmnwvrqapgkglewvsyisrtsktiyy
    adsvkgrftisrdnskntlylqmnslraedtavyycargrffdywgqgtlvtvs
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uziL (L:)
    iqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgeapklliysasvlqsgvpsr
    fsgsgsgtdftltisslqpedfatyycqqsvmipmtfgqgtkve
    

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uziR (R:)
    mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh