PDB entry 2uxn

View 2uxn on RCSB PDB site
Description: structural basis of histone demethylation by lsd1 revealed by suicide inactivation
Class: oxidoreductase/repressor complex
Keywords: histone demethylase, alternative splicing, fad, lsd1, corest, repressor, coiled coil, transcription regulation, oxidoreductase/repressor complex, host-virus interaction, chromatin demethylation, nuclear protein, phosphorylation, chromatin regulator, nucleosomes, transcription, oxidoreductase
Deposited on 2007-03-28, released 2007-05-29
The last revision prior to the SCOP 1.75 freeze date was dated 2007-05-29, with a file datestamp of 2007-07-20.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: 0.242
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2uxna1, d2uxna2, d2uxna3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2uxnb1
  • Chain 'E':
    Compound: Histone H3.1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, FDA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uxnA (A:)
psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
gamytl

    Sequence, based on observed residues (ATOM records): (download) 
    >2uxnA (A:)
gvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfe
atlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsgla
aarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnme
lakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqal
evviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkppr
ditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwh
fanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrq
vrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavq
rmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaa
gimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgnd
ydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflga
mytl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2uxnB (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefgrptetvpqvkkekhstqaknrak
rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
fnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryasas

    Sequence, based on observed residues (ATOM records): (download) 
    >2uxnB (B:)
rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
fnidevlqeweae

  • Chain 'E':
    No sequence available.