PDB entry 2uvy

View 2uvy on RCSB PDB site
Description: structure of pka-pkb chimera complexed with methyl-(4-(9h-purin-6-yl)-benzyl)-amine
Class: transferase/inhibitor
Keywords: transferase/inhibitor, camp, kinase, myristate, transferase, lipoprotein, serine/threonine-protein kinase, nucleotide-binding, protein kinase inhibitor, ATP-binding, nuclear protein, phosphorylation, transferase/inhibitor complex
Deposited on 2007-03-15, released 2007-05-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.218
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UVY
      • engineered mutation (104)
      • engineered mutation (123)
      • engineered mutation (173)
      • engineered mutation (181)
    • Uniprot P00517 (Start-350)
    Domains in SCOPe 2.03: d2uvya_
  • Chain 'I':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GVI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uvyA (A:)
mgnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvml
vkhmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymv
meyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgy
ikvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >2uvyA (A:)
vkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamkil
dkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymvmeyapggemfshlrr
igrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfgfakrvkgr
twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
ipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'I':
    No sequence available.