PDB entry 2tnf

View 2tnf on RCSB PDB site
Description: 1.4 a resolution structure of mouse tumor necrosis factor, towards modulation of its selectivity and trimerisation
Class: cytokine
Keywords: lymphokine, cytokine, cytotoxin, transmembrane, glycoprotein, signal-anchor
Deposited on 1998-10-12, released 1999-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (tumor necrosis factor alpha)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2tnfa_
  • Chain 'B':
    Compound: protein (tumor necrosis factor alpha)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2tnfb_
  • Chain 'C':
    Compound: protein (tumor necrosis factor alpha)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2tnfc_
  • Heterogens: TRS, IPA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2tnfA (A:)
lrsssqnssdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvys
qvlfkgqgcpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylg
gvfqlekgdqlsaevnlpkyldfaesgqvyfgvial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tnfA (A:)
sdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvysqvlfkgqg
cpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylggvfqlekg
dqlsaevnlpkyldfaesgqvyfgvial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2tnfB (B:)
lrsssqnssdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvys
qvlfkgqgcpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylg
gvfqlekgdqlsaevnlpkyldfaesgqvyfgvial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tnfB (B:)
sdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvysqvlfkgqg
cpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylggvfqlekg
dqlsaevnlpkyldfaesgqvyfgvial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2tnfC (C:)
lrsssqnssdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvys
qvlfkgqgcpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylg
gvfqlekgdqlsaevnlpkyldfaesgqvyfgvial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tnfC (C:)
sdkpvahvvanhqveeqlewlsqranallangmdlkdnqlvvpadglylvysqvlfkgqg
cpdyvllthtvsrfaisyqekvnllsavkspcpkdtpegaelkpwyepiylggvfqlekg
dqlsaevnlpkyldfaesgqvyfgvial