PDB entry 2rgp

View 2rgp on RCSB PDB site
Description: Structure of EGFR in complex with hydrazone, a potent dual inhibitor
Class: transferase
Keywords: Kinase domain, Alternative splicing, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Ubl conjugation
Deposited on 2007-10-04, released 2008-08-26
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.228
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2rgpa_
  • Heterogens: PO4, HYZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2rgpA (A:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdadey

    Sequence, based on observed residues (ATOM records): (download) 
    >2rgpA (A:)
allrilketefkkikvlgsgafgtvykglwipvkipvaikelrkankeildeayvmasvd
nphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyled
rrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidadsr
pkfreliiefskmardpqrylviqgdermnfyralmdvvdadey