PDB entry 2r7b

View 2r7b on RCSB PDB site
Description: Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor
Class: signaling protein, transferase
Keywords: PDK1, structure, dibenzonaphthyridine, inhibitor, SIGNALING PROTEIN, TRANSFERASE
Deposited on 2007-09-07, released 2008-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.225
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDPK1, PDK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r7ba_
  • Heterogens: SO4, PSE, 253, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r7bA (A:)
gpamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsre
yaikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngel
lkyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgta
kvlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragne
ylifqkiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtw
enlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >2r7bA (A:)
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlfvgtaqyvspellteksackssdl
walgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatkrl
gceemegygplkahpffesvtwenlhqqtppklt